Ipamorelin

Overview

Selective physiological stimulation of the GH axis.

Mechanism of action

Regulatory note: Ipamorelin is generally discussed as a research compound in many markets rather than an approved medication. Any responsible description should keep claims strictly within “studied” and “investigated” language.

From a plain language perspective, ipamorelin is studied as a signaling trigger that can pulse GH, rather than supplying GH directly. That said, GH axis manipulation is complex: GH and IGF 1 signaling affects metabolism, glucose handling, fluid balance, and tissue growth pathways, so risk depends strongly on context.

Ipamorelin is a growth hormone secretagogue—a compound that stimulates the body’s release of growth hormone (GH) by acting as an agonist at the ghrelin receptor (GHSR) (sometimes historically referred to as the “GHRP receptor”). One key research distinction is that ipamorelin was developed to be relatively selective for GH release, with less activation of stress hormone pathways (ACTH and cortisol) compared with earlier secretagogues in certain studies.

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