MOTS c

Overview

Mitochondria–nucleus communication and metabolic regulation.

Mechanism of action

A responsible description should present MOTS c as a frontier research peptide with strong mechanistic interest and growing literature, but still limited standard clinical adoption.

For general audiences: MOTS c is often described as a “mitochondrial messenger peptide” because mitochondria can send signals that influence how the body manages energy. In mouse studies, MOTS c has been associated with improved metabolic profiles and, in some experiments, enhanced physical capacity—however, these results do not automatically translate into safe, effective human outcomes.

MOTS c is a 16 amino acid mitochondrial derived peptide encoded within mitochondrial DNA and discovered as part of a broader class of mitochondrial signaling peptides. Rather than acting like a typical hormone made in an endocrine gland, MOTS c is considered a metabolic stress response signal, with research linking it to glucose utilization, insulin sensitivity pathways, and cellular adaptation to energetic stress. Mechanistic studies describe interactions with pathways connected to AMPK and folate purine metabolism, as well as nuclear gene regulation relevant to metabolism.

Authenticity

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